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About Us

The Chan Soon-Shiong Institute for Medicine, Immuno-Oncology Network, Mariposa, is a new cancer center that offers state-of-the-art diagnosis, treatment, and access to clinical trials, with a dedicated team of experienced medical professionals who are committed to providing personalized care.

What We Do:

We make molecularly-informed decisions. Our highly-specific tissue & serum diagnostics enable precision therapy based on the unique molecular signature of the tumor across time and space to achieve the optimal therapeutic outcome. Throughout the course of treatment at Chan Soon-Shiong Institute for Medicine at Mariposa, comprehensive genomic, transcriptomic, and proteomic profiling of the patient’s tumor and blood will be used to understand spatiotemporal tumor evolution and direct treatment.

We champion the administration of low-dose chemotherapy and radiotherapy combined with immunotherapy to preserve and retrain the patient’s immune system against their cancer. Growing evidence suggests that transformed cancer cells occur routinely as part of the physiological process of regeneration. In healthy persons, a steady state exists between an Equilibrium phase and Elimination phase, where the natural immune response eliminates malignant cells. When this steady state is overwhelmed by mutations or by the immunosuppressive nature of the tumor microenvironment, the Escape phase ensues, with resultant tumor development, evolution and clinical manifestation. A paradigm shift in cancer care is necessary to overcome the immunogenic disequilibrium of the escape phase.evolution and direct treatment.

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For More Information

1-855-RxRxCSS

1-855-797-9277

Chan Soon-Shiong Institute for Medicine, Immuno-Oncology Network, Mariposa
2040 East Mariposa Avenue
El Segundo, California 90245

We are not currently accepting walk-ins. Please call to schedule an appointment.

Meet the Team

Mira-Kistler-MDMira Kistler, MD

Dr Kistler received her medical degree from the University of Rochester School of Medicine and Dentistry in Rochester, New York, and completed her residency in Internal Medicine at the University of California Los Angeles.

She then spent one year working as a Clinical Instructor in the Hospitalist Division at UCLA and then completed her Fellowship in Hematology and Oncology at UCLA.

During Fellowship, she did focused work and published in area of leukemia and lymphoma. Dr. Kistler joined the Chan Soon-Shiong Institute for Medicine in November 2017.

Dr Kistler received her medical degree from the University of Rochester School of Medicine and Dentistry in Rochester, New York, and completed her residency in Internal Medicine at the University of California Los Angeles. She then spent one year working as a Clinical Instructor in the Hospitalist Division at UCLA and then completed her Fellowship in Hematology and Oncology at UCLA. During Fellowship, she did focused work and published in area of leukemia and lymphoma. Dr. Kistler joined the Chan Soon-Shiong Institute for Medicine in November 2017.


John-H-Lee-M.D-F.A.C.SJohn Lee, MD FACS
Co-Director

John Lee grew up on a small dairy farm in Northern Minnesota. He did his undergraduate education at Stanford University graduating with a B.S. with honors in biology. He received his M.D. degree from the University of Minnesota. Dr. Lee completed residency and fellowship training in Head and Neck Surgery at the University of Iowa.

He stayed on staff and was promoted to associate professor. During time from undergraduate throughout his career he has focused not only on medical training but also translational research.

In 2008, Dr. Lee took a position to build a head and neck cancer program at Sanford Health. While there as the physician lead for the system he developed a large head and neck program that focuses on bringing immune oncology drugs to patients. Academically, he was promoted to full professor and also was promoted to medical director of oncology research. He initiated and chaired the systems protocol review committee for all incoming oncology trials and developed several initiated trials within Sanford.

In addition, his lab produced over 40 peer-reviewed papers, multiple patents and maintained continuous NIH funding. Dr. Lee has a passion is to improve long term cures and reduce morbidity of oncology treatments using the bodies’ immune response.

In 2016, Dr. Lee moved to Southern California to assume the positions of Senior Vice President of Adult Medical Affairs at NantKwest and Co-Director of the Chan Soon-Shiong Institute for Medicine at Mariposa. For enjoyment Dr. Lee enjoys the outdoors, especially hunting and fishing.

John Lee grew up on a small dairy farm in Northern Minnesota. He did his undergraduate education at Stanford University graduating with a B.S. with honors in biology. He received his M.D. degree from the University of Minnesota. Dr. Lee completed residency and fellowship training in Head and Neck Surgery at the University of Iowa.

He stayed on staff and was promoted to associate professor. During time from undergraduate throughout his career he has focused not only on medical training but also translational research. In 2008, Dr. Lee took a position to build a head and neck cancer program at Sanford Health. While there as the physician lead for the system he developed a large head and neck program that focuses on bringing immune oncology drugs to patients. Academically, he was promoted to full professor and also was promoted to medical director of oncology research. He initiated and chaired the systems protocol review committee for all incoming oncology trials and developed several initiated trials within Sanford.

In addition, his lab produced over 40 peer-reviewed papers, multiple patents and maintained continuous NIH funding. Dr. Lee has a passion is to improve long term cures and reduce morbidity of oncology treatments using the bodies’ immune response.

In 2016, Dr. Lee moved to Southern California to assume the positions of Senior Vice President of Adult Medical Affairs at NantKwest and Co-Director of the Chan Soon-Shiong Institute for Medicine at Mariposa. For enjoyment Dr. Lee enjoys the outdoors, especially hunting and fishing.


Chaitali Nangia, MDChaitali Nangia, MD

Chaitali Nangia, MD is the Director of Head and Neck Oncology for the Verity Health System.

Dr. Nangia is a nationally renowned medical oncologist who provides leadership and active involvement in clinical trials focusing on immune oncology, precision care, biologics, targeted drugs and hormonal agents. With her expertise in breast, head, and neck cancers she treats, she focuses on survivorship, quality of life, patient reported outcome and symptom management. Therefore, her goal is for each patient to have a high quality of life during and after treatment.

Dr. Nangia is published in many areas, including head and neck cancers, breast cancers, thyroid cancers, salivary gland tumors, rare tumors and skin cancers. Most recently, she practiced at UC Irvine where she was the HS Associate Clinical professor in the Division of Hematology Oncology and the Associate Program Director for the hematology oncology fellowship program. Dr. Nangia has received many awards, including Teacher of the Year for UC Irvine’s Hematology/Oncology Division or an impressive three times in a row, NCI Clinician Award and Orange County Medical Association Physician of Excellence award.

Chaitali Nangia, MD is the Director of Head and Neck Oncology for the Verity Health System. Dr. Nangia is a nationally renowned medical oncologist who provides leadership and active involvement in clinical trials focusing on immune oncology, precision care, biologics, targeted drugs and hormonal agents. With her expertise in breast, head, and neck cancers she treats, she focuses on survivorship, quality of life, patient reported outcome and symptom management. Therefore, her goal is for each patient to have a high quality of life during and after treatment.

Dr. Nangia is published in many areas, including head and neck cancers, breast cancers, thyroid cancers, salivary gland tumors, rare tumors and skin cancers. Most recently, she practiced at UC Irvine where she was the HS Associate Clinical professor in the Division of Hematology Oncology and the Associate Program Director for the hematology oncology fellowship program. Dr. Nangia has received many awards, including Teacher of the Year for UC Irvine’s Hematology/Oncology Division or an impressive three times in a row, NCI Clinician Award and Orange County Medical Association Physician of Excellence award.


Sandeep Reddy, MDSandeep Reddy, MD

Dr. Reddy received his M.D. from the Geffen School of Medicine at the University of California, Los Angeles after receiving his B.S. in biomedical sciences from the University of California, Riverside. Dr. Reddy was Chief Medical Officer at Caris Life Sciences prior to joining the Chan Soon-Shiong Institute for Medicine at Mariposa. His executive and medical oversight produced over 100 abstracts at major medical conferences and over 30 peer-reviewed publications since 2014.

Previously, Dr. Reddy was Chief of Staff at Los Alamitos Medical Center and actively practicing clinical hematology and oncology.

Simultaneously he held an adjunct faculty position at the Geffen/UCLA School of Medicine as a clinical instructor at Harbor-UCLA Medical Center, where he was awarded the distinguished teaching award for clinical faculty in 2006. He is a member of the Los Angeles Biomedical Institute, ASCO, IASLC and current SWOG investigator. His medical training includes fellowship training in hematology and medical oncology and therapeutics research at the City of Hope, and Internal Medicine residency at Harbor-UCLA Medical Center.

Dr. Reddy received his M.D. from the Geffen School of Medicine at the University of California, Los Angeles after receiving his B.S. in biomedical sciences from the University of California, Riverside. Dr. Reddy was Chief Medical Officer at Caris Life Sciences prior to joining the Chan Soon-Shiong Institute for Medicine at Mariposa. His executive and medical oversight produced over 100 abstracts at major medical conferences and over 30 peer-reviewed publications since 2014.

Previously, Dr. Reddy was Chief of Staff at Los Alamitos Medical Center and actively practicing clinical hematology and oncology. Simultaneously he held an adjunct faculty position at the Geffen/UCLA School of Medicine as a clinical instructor at Harbor-UCLA Medical Center, where he was awarded the distinguished teaching award for clinical faculty in 2006. He is a member of the Los Angeles Biomedical Institute, ASCO, IASLC and current SWOG investigator. His medical training includes fellowship training in hematology and medical oncology and therapeutics research at the City of Hope, and Internal Medicine residency at Harbor-UCLA Medical Center.


Tara E. Seery, MDTara E. Seery, MD

Dr. Tara E. Seery is a medical oncologist who specializes in treating cancers of the pancreas, esophagus, colon, rectum, anus, and liver. She has extensive experience in pancreatic cancer, including multiple publications, and is one of the highest enrollers in an early phase pancreatic cancer trial.

Dr. Seery received her M.D. from University College Dublin School of Medicine after receiving her B.S. from Vanderbilt University. Dr. Seery did her residency and fellowship training in hematology/oncology at Caritas St. Elizabeth Medical Center in Boston and completed her fellowship training at the University of Illinois at Chicago.

Most recently, Dr. Seery was an Associate Professor at UC Irvine in the Division of Hematology Oncology where she received the prestigious C. Ronal Koons, M.D. Humanitarian Award for service and compassion to patients.

Compassion and hope have driven Dr. Seery toward specializing in gastro-intestinal cancers. Although no one in her family is in medicine, she has been passionate about becoming a physician since she was five years old. Dr. Seery states that “joining CSSIFM is exciting because we are offering patients more hope, a better quality of life, and our future is to cure cancer.” Her plan is to help lead the pancreatic cancer studies for CSSIFM.

She enjoys teaching and was recently featured at the Hematology/Oncology Fellowship Annual Lecture Series. Her research experience includes neoadjuvant chemotherapy and intraoperative chemotherapy for resectable pancreatic cancer and Corydalis Yanhusuo for prevention of chemotherapy induced neuropathy. She has been the primary investigator for 20 oncology trials. Dr. Seery has been published numerous times, has many abstracts, and is an invited speaker around the world.

Dr. Seery has lived in Southern California since 2010, enjoys running and spending time with her husband and young daughter.

Dr. Tara E. Seery is a medical oncologist who specializes in treating cancers of the pancreas, esophagus, colon, rectum, anus, and liver. She has extensive experience in pancreatic cancer, including multiple publications, and is one of the highest enrollers in an early phase pancreatic cancer trial.

Dr. Seery received her M.D. from University College Dublin School of Medicine after receiving her B.S. from Vanderbilt University. Dr. Seery did her residency and fellowship training in hematology/oncology at Caritas St. Elizabeth Medical Center in Boston and completed her fellowship training at the University of Illinois at Chicago.

Most recently, Dr. Seery was an Associate Professor at UC Irvine in the Division of Hematology Oncology where she received the prestigious C. Ronal Koons, M.D. Humanitarian Award for service and compassion to patients.

Compassion and hope have driven Dr. Seery toward specializing in gastro-intestinal cancers. Although no one in her family is in medicine, she has been passionate about becoming a physician since she was five years old. Dr. Seery states that “joining CSSIFM is exciting because we are offering patients more hope, a better quality of life, and our future is to cure cancer.” Her plan is to help lead the pancreatic cancer studies for CSSIFM.

She enjoys teaching and was recently featured at the Hematology/Oncology Fellowship Annual Lecture Series. Her research experience includes neoadjuvant chemotherapy and intraoperative chemotherapy for resectable pancreatic cancer and Corydalis Yanhusuo for prevention of chemotherapy induced neuropathy. She has been the primary investigator for 20 oncology trials. Dr. Seery has been published numerous times, has many abstracts, and is an invited speaker around the world.

Dr. Seery has lived in Southern California since 2010, enjoys running and spending time with her husband and young daughter.


Lennie Sender, MDLennie Sender, MD
Co-Director

Dr. Sender received his M.D. degree at the University of the Witwatersrand in Johannesburg, South Africa. He completed internship and residency in pediatrics at the University of California, Irvine and a fellowship in pediatric hematology-oncology at Children’s Hospital Los Angeles.

In his more than 20 years of experience treating pediatric, adolescent, and young adult cancer patients and survivors, he has seen how the field of oncology has changed and how concerted efforts are now made to address patients’ ancillary needs, including fertility preservation, management of acute and chronic treatment effects, and to be sensitive to the psychosocial impacts of a cancer diagnosis on those just beginning their most productive years.

Dr. Sender’s research interests are comprehensive and multidisciplinary, extending from epidemiological components (incidence, prevalence), to biological factors (genomic or cellular differences), to the psychosocial impact of cancer, to long-term cancer survivorship. In 2011, Dr. Sender was the recipient of a $10 million Hyundai Hope on Wheels grant to study the genomic basis of pediatric and adolescent and young adult cancers to test the hypothesis that genomic knowledge can enable clinical decisions related to treatment options. In 2010, he founded two entities critical to the development of the emerging adolescent and young adult (AYA) oncology subspecialty as President of the Society for Adolescent and Young Adult Oncology (SAYAO) and Editor-in-Chief of the Journal of Adolescent and Young Adult Oncology (JAYAO). Dr. Sender currently serves as the Medical Director of the Hyundai Cancer Institute at CHOC Children’s and has recently been named as the Senior Vice President of Medical Affairs for Pediatric, Adolescent and Young Adult Oncology for NantKwest.

Prior to joining NantKwest, Dr. Sender was the Medical Director of Clinical Oncology at the University of California’s NCI designated Chao Family Comprehensive Cancer Center. Dr. Sender also serves as Co-Director of the Chan Soon-Shiong Institute for Medicine at Mariposa.

Dr. Sender received his M.D. degree at the University of the Witwatersrand in Johannesburg, South Africa. He completed internship and residency in pediatrics at the University of California, Irvine and a fellowship in pediatric hematology-oncology at Children’s Hospital Los Angeles.

In his more than 20 years of experience treating pediatric, adolescent, and young adult cancer patients and survivors, he has seen how the field of oncology has changed and how concerted efforts are now made to address patients’ ancillary needs, including fertility preservation, management of acute and chronic treatment effects, and to be sensitive to the psychosocial impacts of a cancer diagnosis on those just beginning their most productive years. Dr. Sender’s research interests are comprehensive and multidisciplinary, extending from epidemiological components (incidence, prevalence), to biological factors (genomic or cellular differences), to the psychosocial impact of cancer, to long-term cancer survivorship. In 2011, Dr. Sender was the recipient of a $10 million Hyundai Hope on Wheels grant to study the genomic basis of pediatric and adolescent and young adult cancers to test the hypothesis that genomic knowledge can enable clinical decisions related to treatment options. In 2010, he founded two entities critical to the development of the emerging adolescent and young adult (AYA) oncology subspecialty as President of the Society for Adolescent and Young Adult Oncology (SAYAO) and Editor-in-Chief of the Journal of Adolescent and Young Adult Oncology (JAYAO). Dr. Sender currently serves as the Medical Director of the Hyundai Cancer Institute at CHOC Children’s and has recently been named as the Senior Vice President of Medical Affairs for Pediatric, Adolescent and Young Adult Oncology for NantKwest.

Prior to joining NantKwest, Dr. Sender was the Medical Director of Clinical Oncology at the University of California’s NCI designated Chao Family Comprehensive Cancer Center. Dr. Sender also serves as Co-Director of the Chan Soon-Shiong Institute for Medicine at Mariposa.


Paula Bradshaw RN, MSN, MBA Clinic AdministratorPaula Bradshaw
RN, MSN, MBA

Vice President, Clinic Operations

Ms. Paula Bradshaw has 28 years’ experience in the healthcare arena. She trained and worked as a critical care nurse in the United Kingdom for 11 years. Paula joined the Nant family in 2016, and is currently the Vice President, Clinic Operations for the Chan Soon-Shiong Institute for Medicine Immuno-Oncology Network, Mariposa.

In 2001, Paula came to the United States and joined Saint John’s Health Center, Santa Monica as an advanced practice nurse, where she established an end of life, and pain management nursing program. In 2003, Paula was promoted to Director, Risk Management.

By 2006, Paula completed her MSN and MBA, and her responsibilities at Saint John’s expanded, she had responsibility for risk, case management, healthcare quality, regulatory compliance, and John Wayne Cancer Centers. In 2010, she transitioned from the hospital to become Chief Nursing Officer at a software company, where she was responsible for software design, data analysis, and all client facing activity.

Ms. Paula Bradshaw has 28 years’ experience in the healthcare arena. She trained and worked as a critical care nurse in the United Kingdom for 11 years. Paula joined the Nant family in 2016, and is currently the Vice President, Clinic Operations for the Chan Soon-Shiong Institute for Medicine Immuno-Oncology Network, Mariposa.

In 2001, Paula came to the United States and joined Saint John’s Health Center, Santa Monica as an advanced practice nurse, where she established an end of life, and pain management nursing program. In 2003, Paula was promoted to Director, Risk Management.

By 2006, Paula completed her MSN and MBA, and her responsibilities at Saint John’s expanded, she had responsibility for risk, case management, healthcare quality, regulatory compliance, and John Wayne Cancer Centers. In 2010, she transitioned from the hospital to become Chief Nursing Officer at a software company, where she was responsible for software design, data analysis, and all client facing activity.


Shirley-BotezatuShirley Botezatu, RN
Director, Clinic Administrator

Ms. Shirley Botezatu is the Director, Clinic Administrator for the Chan Soon-Shiong Institute for Medicine Immuno-Oncology Network, Mariposa. She has been a nurse for over 30 years and has worked in a variety of health care areas including critical care, preventative health, rehabilitation and now oncology.

She joined the Nant family in 2014, as a clinical analyst, providing support in implementation and offering clinical input into Nanthealth’s numerous health care solutions.

In 2015, she helped to establish the Nantcare Engagement Network and worked as a nurse navigator, responding to all inquiries about our GPS testing from oncology providers and patients suffering from cancer. 2016 found her the Director of the Wellness Call Center for Nanthealth, overseeing health coaches and subject matter experts whose primary focus was health and wellness. She is currently the Director, Clinic Administrator for the Chan Soon-Shiong Institute for Medicine Immuno-Oncology Network, Mariposa

Ms. Shirley Botezatu is the Director, Clinic Administrator for the Chan Soon-Shiong Institute for Medicine Immuno-Oncology Network, Mariposa. She has been a nurse for over 30 years and has worked in a variety of health care areas including critical care, preventative health, rehabilitation and now oncology.

She joined the Nant family in 2014, as a clinical analyst, providing support in implementation and offering clinical input into Nanthealth’s numerous health care solutions. In 2015, she helped to establish the Nantcare Engagement Network and worked as a nurse navigator, responding to all inquiries about our GPS testing from oncology providers and patients suffering from cancer. 2016 found her the Director of the Wellness Call Center for Nanthealth, overseeing health coaches and subject matter experts whose primary focus was health and wellness. She is currently the Director, Clinic Administrator for the Chan Soon-Shiong Institute for Medicine Immuno-Oncology Network, Mariposa


Lauren-Wagner-RN,-OCNLauren Wagner RN, OCN

Lauren Wagner RN, OCN has over ten years’ experience in the healthcare field with her primary focus in Oncology. She is an Oncology Certified Nurse, highly skilled in Navigation, Clinical Research, Chemotherapy Administration as well as Patient Education.

Lauren began her nursing career at Orange Coast Memorial Medical Center, first as a Staff RN, then Nursing Preceptor as well as Charge Nurse.

She was then later promoted to Clinical Supervisor both on the Inpatient Oncology Unit and Outpatient Infusion Center. Lauren then explored other options in the oncology nursing field and joined UC Irvine as a Nurse Navigator in the Breast Center at the Chao Comprehensive Cancer Center. Lauren joined the Nant family in 2016 as a GPS Nurse Navigator for NantHealth and is currently the Nurse Navigator for the Chan Soon-Shiong Institute for Medicine Immuno-Oncology Network, Mariposa.

Lauren Wagner RN, OCN has over ten years’ experience in the healthcare field with her primary focus in Oncology. She is an Oncology Certified Nurse, highly skilled in Navigation, Clinical Research, Chemotherapy Administration as well as Patient Education.

Lauren began her nursing career at Orange Coast Memorial Medical Center, first as a Staff RN, then Nursing Preceptor as well as Charge Nurse. She was then later promoted to Clinical Supervisor both on the Inpatient Oncology Unit and Outpatient Infusion Center. Lauren then explored other options in the oncology nursing field and joined UC Irvine as a Nurse Navigator in the Breast Center at the Chao Comprehensive Cancer Center.

Lauren joined the NANT family in 2014 as a GPS Nurse Navigator for NantHealth and is currently the Nurse Navigator for the Chan Soon-Shiong Institute for Medicine Immuno-Oncology Network, Mariposa

Conflict of Interest Policy

The Chan Soon-Shiong Institute for Medicine, Immuno-Oncology Network, Mariposa (CSSIFM) acknowledges the importance of conflict of interest management which is why the Institute has proactively taken the appropriate steps and adopted a Conflict of Interest Policy (COI Policy) that requires comprehensive disclosure of the financial interests of Investigators conducting clinical research at the CSSIFM. See Conflict of Interest (COI) Policy which has been implemented in full prior to opening of the Institute.

For More Information

1-855-RxRxCSS

1-855-797-9277

Chan Soon-Shiong Institute for Medicine, Immuno-Oncology Network, Mariposa
2040 East Mariposa Avenue
El Segundo, California 90245

We are not currently accepting walk-ins. Please call to schedule an appointment.